Synthetic Lethality in Cancer

Synthetic lethality is a concept that tells that if the function of a single gene is affected the survival of a cell remains unaffected and when functions of both the genes are lost, then it results in cell death. This concept has been used in cancer therapies these days and most commonly used in the case of tumor suppressor genes. Blocking the function of another gene product of TSG, renders the TSG to be active and hence can control the growth of tumor cells.

  • Track 1-1 Loss of function
  • Track 2-2 Cell death
  • Track 3-3 Cancer therapies

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